Modeled Reductions in Late-stage Cancer with a Multi-Cancer Early Detection Test

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Disease Area (Primary)

Cancer

Disease Area (Secondary)

First Developed

01/13/2020

Last Developed

Software Used

R (e.g., heemod, BCEA, dampack, hesim)

Model Sponsor

Pharmaceutical or medical device company

Intervention

screening

Model Validation Score

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Results

The MCED test could intercept 485 cancers per year per 100,000 persons, reducing late-stage (III-IV) incidence by 78% in those intercepted. Accounting for lead time, this could reduce 5-year cancer mortality by 39% in those intercepted, resulting in an absolute reduction of 104 deaths per 100,000, or 26% of all cancer-related deaths. Findings are robust across tumor growth scenarios.

Conclusion

What are the key conclusions or current applications of this model?

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Summary
Validation Score

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